From Charleston, SC
Take I-26 West towards Orangeburg. After traveling approximately 70 miles, you should approach the Orangeburg exits. Take exit 145A / US-601 toward Orangeburg. Travel approximately 4 miles. Turn left onto SC State Campus.
From Columbia, SC
Take I-26 East towards Orangeburg. After traveling approximately 40 miles, you should approach the Orangeburg exits. Take exit 145A / US-601 toward Orangeburg. Travel approximately 4 miles. Turn left onto SC State Campus.